Chapter 4 Adolescent nicotine exposure transiently increases high - affinity nicotinic receptor expression in the rat medial prefrontal cortex
نویسندگان
چکیده
Departments of 1Molecular and Cellular Neurobiology, Center for Neurogenomics & Cognitive Research, Neuroscience Campus Amsterdam, VU University, The Netherlands 2Analytical Chemistry & Applied Spectroscopy, VU University, The Netherlands 3Anatomy and Neurosciences, VU Medical Center, The Netherlands, 4Department of Medical Pharmacology, Cellular and Molecular Pharmacology, CNR, Institute of Neuroscience, University of Milan, Milan, Italy. *Authors contributed equally
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Adolescent nicotine exposure transiently increases high-affinity nicotinic receptors and modulates inhibitory synaptic transmission in rat medial prefrontal cortex.
Adolescence is a critical developmental period during which most adult smokers initiate their habit. Adolescents are more vulnerable than adults to nicotine's long-term effects on addictive and cognitive behavior. We investigated whether adolescent nicotine exposure in rats modifies expression of nicotinic acetylcholine receptors (nAChRs) in medial prefrontal cortex (mPFC) in the short and/or l...
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